Genetic risk for major depressive disorder and loneliness in sex-specific associations with coronary artery disease.

ABSTRACT: Major depressive disorder (MDD) and loneliness are phenotypically and genetically correlated with coronary artery disease (CAD), but whether these associations are explained by pleiotropic genetic variants or shared comorbidities is unclear. To tease apart these scenarios, we first assessed the medical morbidity pattern associated with genetic risk factors for MDD and loneliness by conducting a phenome-wide association study in 18,385 European-ancestry individuals in the Vanderbilt University Medical Center biobank, BioVU. Polygenic scores for MDD and loneliness were developed for each person using previously published meta-GWAS summary statistics, and were tested for association with 882 clinical diagnoses ascertained via billing codes in electronic health records. We discovered strong as

SUBMITTER: Dennis J 

PROVIDER: S-EPMC7266730 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature