A network of phosphatidylinositol (4,5)-bisphosphate (PIP₂) binding sites on the dopamine transporter regulates amphetamine behavior in Drosophila Melanogaster.

ABSTRACT: Reward modulates the saliency of a specific drug exposure and is essential for the transition to addiction. Numerous human PET-fMRI studies establish a link between midbrain dopamine (DA) release, DA transporter (DAT) availability, and reward responses. However, how and whether DAT function and regulation directly participate in reward processes remains elusive. Here, we developed a novel experimental paradigm in Drosophila melanogaster to study the mechanisms underlying the psychomotor and rewarding properties of amphetamine (AMPH). AMPH principally mediates its pharmacological and behavioral effects by increasing DA availability through the reversal of DAT function (DA efflux). We have previously shown that the phospholipid, phosphatidylinositol (4, 5)-bisphosphate (PIP₂), dir

SUBMITTER: Belovich AN 

PROVIDER: S-EPMC7266731 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature