Voltammetric sensing of recombinant viral dengue virus 2 NS1 based on Au nanoparticle-decorated multiwalled carbon nanotube composites.

ABSTRACT: A homemade gold electrode is modified with a carbon nanotubes/gold nanoparticles nanocomposite to perform selective and sensitive electrochemical detection of dengue toxin. This nanostructured composite offers a large specific surface and a reactive interface allowing the immobilization of biological material. Dengue antibodies are immobilized on gold nanoparticles via covalent bonding for dengue toxin detection. The porous tridimensional network of carbon nanotubes and gold nanoparticles enhances the electrochemical signal and the overall performance of the sensor. After optimization, the system exhibits a high sensitivity of - 0.44 ± 0.01 μA per decade with wide linear range between 1 × 10^-12 and 1 × 10^-6 g/mL at a working potential of 0.22 V vs Ag/AgCl. The extreme

SUBMITTER: Palomar Q 

PROVIDER: S-EPMC7266806 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature