No association between FKBP5 gene methylation and acute and long-term cortisol output.

ABSTRACT: Prior studies identified DNA methylation (DNA_M) changes in a regulatory region within the FK506 binding protein 5 (FKBP5) gene as a crucial mediator of long-term negative health outcomes following early adversity. A critical mechanism underlying this link, in turn, has been suggested to be epigenetically induced dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis. The purpose of this study was thus to investigate associations of FKBP5 DNA_M with both acute and chronic cortisol output. Two hundred adults with differential exposure to childhood trauma (CT) were underwent a laboratory stressor (Trier Social Stress Test) and provided salivary samples for the analysis of acute cortisol stress responses. In addition, hair cortisol concentrations were determined as

SUBMITTER: Alexander N 

PROVIDER: S-EPMC7266811 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature