CD137 costimulation enhances the antiviral activity of Vγ9Vδ2-T cells against influenza virus.

ABSTRACT: Influenza epidemics and pandemics are constant threats to global public health. Although strategies including vaccines and antiviral drugs have achieved great advances in controlling influenza virus infection, the efficacy of these strategies is limited by the highly frequent mutations in the viral genome and the emergence of drug-resistant strains. Our previous study indicated that boosting the immunity of human Vγ9Vδ2-T cells with the phosphoantigen pamidronate could be a therapeutic strategy to treat seasonal and avian influenza virus infections. However, one notable drawback of γδ-T cell-based immunotherapy is the rapid exhaustion of proliferation and effector responses due to repeated treatments with phosphoantigens. Here, we found that the expression of CD137 was inducible in Vγ9Vδ2-

SUBMITTER: Pei Y 

PROVIDER: S-EPMC7266814 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature