Obesity and Sex Affect the Immune Responses to Tick-Borne Encephalitis Booster Vaccination.

ABSTRACT: Obesity has dramatically increased over the last 30 years and reaches according to World Health Organization dimensions of a global epidemic. The obesity-associated chronic low-level inflammation contributes to severe comorbidities and directly affects many immune cells leading to immune dysfunction and increased susceptibility to infections. Thus, prophylaxis against vaccine-preventable diseases is crucial, yet the responsiveness to several vaccines is unclear under obesity. In order to assess the responsiveness to tick-borne encephalitis (TBE) vaccine, we revaccinated 37 obese individuals and 36 normal-weight controls with a licensed TBE vaccine. Metabolic, hormonal, and immunologic profiles along with vaccine-specific humoral and cellular immune responses were evaluated in sera and peri

SUBMITTER: Garner-Spitzer E 

PROVIDER: S-EPMC7266951 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature