Cord Blood Platelet Rich Plasma Derivatives for Clinical Applications in Non-transfusion Medicine.

ABSTRACT: Cord blood platelet rich plasma (CB-PRP) derivatives have been investigated as potential therapeutic agents for the treatment of diverse conditions including ocular surface disease and skin ulcers. We have developed processes for the formulation of several CB-PRP preparations, which have different composition and attributes. Here we describe the molecular characteristics of these preparations and we make recommendations as to their most appropriate clinical application based on functional and immunomodulatory profiles. We show that incubation of adult peripheral blood mononuclear cells (PBMCs) with all three preparations dramatically reduced the production of INFγ and the expression of NKG2D and CD107a in NK, NKT, and T cells thus diminishing their activation, we propose that the likely me

SUBMITTER: Samarkanova D 

PROVIDER: S-EPMC7266986 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature