Altered Topological Patterns of Gray Matter Networks in Tinnitus: A Graph-Theoretical-Based Study.

ABSTRACT:

Objective

Tinnitus is a prevalent hearing disorder, which could have a devastating impact on a patient's life. Functional studies have revealed connectivity pattern changes in the tinnitus brains that suggested a change of network dynamics as well as topological organization. However, no studies have yet provided evidence for the topological network changes in the gray matter. In this research, we aim to use the graph-theoretical approach to investigate the changes of topology in the tinnitus brain using structural MRI data, which could provide insights into the underlying anatomical basis for the neural mechanism in generating phantom sounds.

Methods

We collected 3D MRI images on 46 bilateral tinnitus patients and 46 age and gender-matched healthy controls. Brain networks w

SUBMITTER: Lin X 

PROVIDER: S-EPMC7267018 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature