Longitudinal Association Between Markers of Liver Injury and Mortality in COVID-19 in China.

ABSTRACT:

Background and aims

Coronavirus disease 2019 (COVID-19) is a new infectious disease. To reveal the hepatic injury related to this disease and its clinical significance, we conducted a multicenter retrospective cohort study that included 5,771 adult patients with COVID-19 pneumonia in Hubei Province.

Approach and results

We reported the distributional and temporal patterns of liver injury indicators in these patients and determined their associated factors and death risk. Longitudinal liver function tests were retrospectively analyzed and correlated with the risk factors and death. Liver injury dynamic patterns differed in alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and total bilirubin (TBIL). AST elevated first, followed by A

SUBMITTER: Lei F 

PROVIDER: S-EPMC7267515 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature