Epigallocatechin gallate inhibits dimethylhydrazine-induced colorectal cancer in rats.

ABSTRACT:

Background

Epigallocatechin gallate (EGCG) is a polyhydroxy phenolic compound extracted from tea and its antitumor effect has received widespread attention. We explored the inhibitory effect of EGCG on dimethylhydrazine (DMH)-induced colorectal cancer (CRC) using a rat model, predicted the interaction between EGCG and CRC target genes using a database, and explained the EGCG associated target pathways and mechanisms in CRC.

Aim

To understand the inhibitory mechanisms of EGCG on CRC cell proliferation and identify its pharmacological targets by network pharmacology analysis.

Methods

DMH (40 mg/kg, s.c., twice weekly for eight weeks) was used to induce CRC in rats. After model establishment, the rats were administered with EGCG (50, 100, or 200 mg/kg, p.o., once daily f

SUBMITTER: Wang Y 

PROVIDER: S-EPMC7267698 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature