Network pharmacology to dissect the mechanisms of Yinlai Decoction for pneumonia.

ABSTRACT:

Background

Pneumonia is a common respiratory disorder, which brings an enormous financial burden to the medical system. However, the current treatment options for pneumonia are limited because of drug resistance and side effects. Our previous study preliminarily confirmed that Yinlai Decoction (YD), a common prescription for pneumonia in clinical practice, can regulate the expression of inflammatory factors, but the mechanisms are unknown yet.

Methods

In our work, a method named network pharmacology was applied, which investigated the underlying mechanisms of herbs based on a variety of databases. We obtained bioactive ingredients of YD on TCMSP database and collected potential targets of these ingredients by target fishing. Then the pneumonia-related targets database was bu

SUBMITTER: Xu J 

PROVIDER: S-EPMC7267769 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature