The Glycine Receptor Allosteric Ligands Library (GRALL).

ABSTRACT:

Motivation

Glycine receptors (GlyRs) mediate fast inhibitory neurotransmission in the brain and have been recognized as key pharmacological targets for pain. A large number of chemically diverse compounds that are able to modulate GlyR function both positively and negatively have been reported, which provides useful information for the development of pharmacological strategies and models for the allosteric modulation of these ion channels.

Results

Based on existing literature, we have collected 218 unique chemical entities with documented modulatory activities at homomeric GlyR-α1 and -α3 and built a database named GRALL. This collection includes agonists, antagonists, positive and negative allosteric modulators and a number of experimentally inactive compounds. Most importa

SUBMITTER: Cerdan AH 

PROVIDER: S-EPMC7267813 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature