Effect of Suvorexant vs Placebo on Total Daytime Sleep Hours in Shift Workers: A Randomized Clinical Trial.

ABSTRACT:

Importance

Many shift workers have difficulty sleeping during the daytime owing to an inappropriately timed circadian drive for wakefulness.

Objective

To determine whether a dual hypocretin receptor antagonist would enable shift workers to have more daytime sleep.

Design, setting, and participants

This double-blind, placebo-controlled randomized clinical trial included 2 weeks of baseline data and 3 weeks of intervention data, from March 2016 to December 2018. Individuals were recruited through poster advertisements in the broader San Francisco Bay area in California. From an initial voluntary recruitment cohort of 38 shift workers, 19 individuals with self-reported difficulty sleeping during the daytime following night work shift were included. Data were analyzed fro

SUBMITTER: Zeitzer JM 

PROVIDER: S-EPMC7267849 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature