Alterations in Vaginal Microbiota and Associated Metabolome in Women with Recurrent Implantation Failure.

ABSTRACT: Recurrent implantation failure (RIF) refers to repeated failure to become pregnant after transferring embryos with normal morphology. However, the pathogenesis of RIF remains unrevealed, especially for those without any pathological features. In this study, we characterized the vaginal microbiota and metabolomes of patients with unexplained RIF, while patients who achieved clinical pregnancy in the first frozen embryo transfer (FET) cycle were used as controls. Based on 16S rRNA gene sequencing of the vaginal microbiota, the vaginal Lactobacillus showed a significant positive correlation with the pregnancy rate, and the RIF group presented higher microbial α-diversity than the control group (P value = 0.016). The metabolomic profile identified 2,507 metabolites, of which 37 w

SUBMITTER: Fu M 

PROVIDER: S-EPMC7267891 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature