Longitudinal trajectory of Amyloid-related hippocampal subfield atrophy in nondemented elderly.

ABSTRACT: Hippocampal atrophy and abnormal β-Amyloid (Aβ) deposition are established markers of Alzheimer's disease (AD). Nonetheless, longitudinal trajectory of Aβ-associated hippocampal subfield atrophy prior to dementia remains unclear. We hypothesized that elevated Aβ correlated with longitudinal subfield atrophy selectively in no cognitive impairment (NCI), spreading to other subfields in mild cognitive impairment (MCI). We analyzed data from two independent longitudinal cohorts of nondemented elderly, including global PET-Aβ in AD-vulnerable cortical regions and longitudinal subfield volumes quantified with a novel auto-segmentation method (FreeSurfer v.6.0). Moreover, we investigated associations of Aβ-related progressive subfield atrophy with memory decline. Across both datasets, we found a

SUBMITTER: Zhang L 

PROVIDER: S-EPMC7267893 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature