Metabolic and vascular risk factors are associated with reduced cerebral blood flow and poorer midlife memory performance.

ABSTRACT: Midlife metabolic and vascular risk factors (MVRFs) predict cognitive decline and dementia; however, these risk factors tend to overlap, and the mechanisms underlying their effects on cognitive performance are not well understood. This cross-sectional study investigates the contributions of MVRFs to regional cerebral blood flow (CBF) and verbal learning & memory among middle-aged adults. We used partial least squares (PLS) analysis to create latent risk factor profiles and examine their associations to CBF in 93 regions of interest among 451 participants (age 50.3 ± 3.5 years) of the Coronary Artery Risk Development in Young Adults. This multivariate analysis revealed regional CBF was lower in relation to obesity (higher body mass index and waist circumference), dysregulated glucose homeos

SUBMITTER: MacIntosh BJ 

PROVIDER: S-EPMC7267901 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature