Baseline functional connectivity may predict placebo responses to accelerated rTMS treatment in major depression.

ABSTRACT: Although in theory sham repetitive transcranial magnetic stimulation (rTMS) has no inherent therapeutic value, nonetheless, such placebo stimulations may have relevant therapeutic effects in clinically depressed patients. On the other hand, antidepressant responses to sham rTMS are quite heterogeneous across individuals and its neural underpinnings have not been explored yet. The current brain imaging study aims to detect baseline neural fingerprints resulting in clinically beneficial placebo rTMS treatment responses. We collected resting-state functional magnetic resonance imaging data prior to a registered randomized clinical trial of accelerated placebo stimulation protocol in patients documented with treatment-resistant depression (http://clinicaltrials.gov/show/NCT01832805). In additi

SUBMITTER: Wu GR 

PROVIDER: S-EPMC7267925 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature