Impaired interactions among white-matter functional networks in antipsychotic-naive first-episode schizophrenia.

ABSTRACT: Schizophrenia has been conceptualized as a disorder arising from structurally pathological alterations to white-matter fibers in the brain. However, few studies have focused on white-matter functional changes in schizophrenia. Considering that converging evidence suggests that white-matter resting state functional MRI (rsfMRI) signals can effectively depict neuronal activity and psychopathological status, this study examined white-matter network-level interactions in antipsychotic-naive first-episode schizophrenia (FES) to facilitate the interpretation of the psychiatric pathological mechanisms in schizophrenia. We recruited 42 FES patients (FESs) and 38 healthy controls (HCs), all of whom underwent rsfMRI. We identified 11 white-matter functional networks, which could be further classifie

SUBMITTER: Fan YS 

PROVIDER: S-EPMC7267955 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature