Cortical laminar resting-state signal fluctuations scale with the hypercapnic blood oxygenation level-dependent response.

ABSTRACT: Calibrated functional magnetic resonance imaging can remove unwanted sources of signal variability in the blood oxygenation level-dependent (BOLD) response. This is achieved by scaling, using information from a perfusion-sensitive scan during a purely vascular challenge, typically induced by a gas manipulation or a breath-hold task. In this work, we seek for a validation of the use of the resting-state fluctuation amplitude (RSFA) as a scaling factor to remove vascular contributions from the BOLD response. Given the peculiarity of depth-dependent vascularization in gray matter, BOLD and vascular space occupancy (VASO) data were acquired at submillimeter resolution and averaged across cortical laminae. RSFA from the primary motor cortex was, thus, compared to the amplitude of hypercapnia-in

SUBMITTER: Guidi M 

PROVIDER: S-EPMC7267967 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature