A fixel-based analysis of micro- and macro-structural changes to white matter following adult traumatic brain injury.

ABSTRACT: Diffusion tensor imaging is often used to assess white matter (WM) changes following traumatic brain injury (TBI), but is limited in voxels that contain multiple fibre tracts. Fixel-based analysis (FBA) addresses this limitation by using a novel method of analysing high angular resolution diffusion-weighted imaging (HARDI) data. FBA examines three aspects of each fibre tract within a voxel: tissue micro-structure (fibre density [FD]), tissue macro-structure (fibre-bundle cross section [FC]) and a combined measure of both (FD and fibre-bundle cross section [FDC]). This study used FBA to identify the location and extent of micro- and macro-structural changes in WM following TBI. A large TBI sample (N_mild = 133, N_{moderate-severe} = 29) and control group (healthy and ortho

SUBMITTER: Wallace EJ 

PROVIDER: S-EPMC7268050 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature