The role of BDNF methylation and Val⁶⁶ Met in amygdala reactivity during emotion processing.

ABSTRACT: Epigenetic alterations of the brain-derived neurotrophic factor (BDNF) gene have been associated with psychiatric disorders in humans and with differences in amygdala BDNF mRNA levels in rodents. This human study aimed to investigate the relationship between the functional BDNF-Val⁶⁶ Met polymorphism, its surrounding DNA methylation in BDNF exon IX, amygdala reactivity to emotional faces, and personality traits. Healthy controls (HC, n = 189) underwent functional MRI during an emotional face-matching task. Harm avoidance, novelty seeking and reward dependence were measured using the Tridimensional Personality Questionnaire (TPQ). Individual BDNF methylation profiles were ascertained and associated with several BDNF single nucleotide polymorphisms surrounding the BDNF-Val^66<

SUBMITTER: Redlich R 

PROVIDER: S-EPMC7268057 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature