Replicable brain signatures of emotional bias and memory based on diffusion kurtosis imaging of white matter tracts.

ABSTRACT: Diffusion MRI (dMRI) is sensitive to anisotropic diffusion within bundles of nerve axons and can be used to make objective measurements of brain networks. Many brain disorders are now recognised as being caused by network dysfunction or are secondarily associated with changes in networks. There is therefore great potential in using dMRI measures that reflect network integrity as a future clinical tool to help manage these conditions. Here, we used dMRI to identify replicable, robust and objective markers that meaningfully reflect cognitive and emotional performance. Using diffusion kurtosis analysis and a battery of cognitive and emotional tests, we demonstrated strong relationships between white matter structure across networks of anatomically and functionally specific brain regions with

SUBMITTER: Welton T 

PROVIDER: S-EPMC7268065 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature