Longitudinal stability of the brain functional connectome is associated with episodic memory performance in aging.

ABSTRACT: The brain functional connectome forms a relatively stable and idiosyncratic backbone that can be used for identification or "fingerprinting" of individuals with a high level of accuracy. While previous cross-sectional evidence has demonstrated increased stability and distinctiveness of the brain connectome during the course of childhood and adolescence, less is known regarding the longitudinal stability in middle and older age. Here, we collected structural and resting-state functional MRI data at two time points separated by 2-3 years in 75 middle-aged and older adults (age 49-80, SD = 6.91 years) which allowed us to assess the long-term stability of the functional connectome. We show that the connectome backbone generally remains stable over a 2-3 years period in middle and older age. In

SUBMITTER: Ousdal OT 

PROVIDER: S-EPMC7268077 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature