Brain connectivity markers for the identification of effective contacts in subthalamic nucleus deep brain stimulation.

ABSTRACT: The clinical benefit of deep brain stimulation (DBS) for Parkinson's disease (PD) is relevant to the tracts adjacent to the stimulation site, but it remains unclear what connectivity pattern is associated with effective DBS. The aim of this study was to identify clinically effective electrode contacts on the basis of brain connectivity markers derived from diffusion tensor tractography. We reviewed 77 PD patients who underwent bilateral subthalamic nucleus DBS surgery. The patients were assigned into the training (n = 58) and validation (n = 19) groups. According to the therapeutic window size, all contacts were classified into effective and ineffective groups. The whole-brain connectivity of each contact's volume of tissue activated was estimated using tractography with preoperative diffu

SUBMITTER: Lin H 

PROVIDER: S-EPMC7268081 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature