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Controlled, double-blind, randomized trial to assess the efficacy and safety of hydroxychloroquine chemoprophylaxis in SARS CoV2 infection in healthcare personnel in the hospital setting: A structured summary of a study protocol for a randomised controlled trial.


ABSTRACT:

SUBMITTER: Cuadrado-Lavin A 

PROVIDER: S-EPMC7268173 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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Controlled, double-blind, randomized trial to assess the efficacy and safety of hydroxychloroquine chemoprophylaxis in SARS CoV2 infection in healthcare personnel in the hospital setting: A structured summary of a study protocol for a randomised controlled trial.

Cuadrado-Lavín Antonio A   Olmos José Manuel JM   Cifrian José Manuel JM   Gimenez Teresa T   Gandarillas Marco Antonio MA   García-Saiz Mar M   Rebollo Maria Henar MH   Martínez-Taboada Victor V   López-Hoyos Marcos M   Fariñas María Carmen MC   Crespo Javier J  

Trials 20200603 1


<h4>Background</h4>SARS-CoV-2 infection presents a high transmission in the group of health professionals in Spain (12-15% infected). Currently there is no accepted chemoprophylaxis but hydroxychloroquine (HDQ) is known to inhibit the coronavirus in vitro. Our hypothesis is that oral administration of hydroxychloroquine to healthcare professionals can reduce the incidence and prevalence of infection as well as its severity in this group.<h4>Methods</h4>Design: Prospective, single center, double  ...[more]

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