Effect of short-term prescription opioids on DNA methylation of the OPRM1 promoter.

ABSTRACT:

Background

A long-term opioid use has been associated with hypermethylation of the opioid receptor mu 1 (OPRM1) promoter. Very little is currently known about the early epigenetic response to therapeutic opioids. Here, we examine whether we can detect DNA methylation changes associated with a few days' use of prescribed opioids. Genome-wide DNA methylation was assayed in a cohort of 33 opioid-naïve participants who underwent standard dental surgery followed by opioid self-administration. Saliva samples were collected before surgery (visit 1), and at two postsurgery visits at 2.7 ± 1.5 days (visit 2), and 39 ± 10 days (visit 3) after the discontinuation of opioid analgesics.

Results

The perioperative methylome underwent significant changes over the three visits that were prim

SUBMITTER: Sandoval-Sierra JV 

PROVIDER: S-EPMC7268244 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature