Identification of genes and miRNA associated with idiopathic recurrent pregnancy loss: an exploratory data mining study.

ABSTRACT:

Background

Recurrent pregnancy loss (RPL) is a significant adverse pregnancy complication, with an incompletely understood pathology. While many entities were proposed to elucidate the pathogenic basis of RPL, only few were significant enough to warrant investigation in all affected couples.. The aim of this study was to provide novel insights into the biological characteristics and related pathways of differentially expressed miRNA (DEMs) and genes (DEGs), in RPL, and construct a molecular miRNAs-mRNAs network.

Methods

miRNAs and gene expression data were collected, and a number of DEMs and (DEGs) were obtained, and regulatory co-expression network were constructed. Function and enrichment analyses of DEMs were conducted using DIANA-miRPath. DEGs were screened, and were use

SUBMITTER: Bahia W 

PROVIDER: S-EPMC7268288 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature