Urban air particulate matter induces mitochondrial dysfunction in human olfactory mucosal cells.

ABSTRACT:

Background

The adverse effects of air pollutants including particulate matter (PM) on the central nervous system is increasingly reported by epidemiological, animal and post-mortem studies in the last decade. Oxidative stress and inflammation are key consequences of exposure to PM although little is known of the exact mechanism. The association of PM exposure with deteriorating brain health is speculated to be driven by PM entry via the olfactory system. How air pollutants affect this key entry site remains elusive. In this study, we investigated effects of urban size-segregated PM on a novel cellular model: primary human olfactory mucosal (hOM) cells.

Results

Metabolic activity was reduced following 24-h exposure to PM without evident signs of toxicity. Results from cytomet

SUBMITTER: Chew S 

PROVIDER: S-EPMC7268298 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature