Association of circulating SLAMF7⁺Tfh1 cells with IgG4 levels in patients with IgG4-related disease.

ABSTRACT:

Background

Follicular helper CD4⁺ T (Tfh) cells have a critical role in IgG4 production by B cells in IgG4-related disease (IgG4-RD). Recent studies including ours showed that SLAMF7⁺CD4⁺ T cells are an important pathological driver of IgG4-RD. In this study, we have sought to elucidate a relationship between helper CD4⁺ T (Th), particularly Tfh, cells and SLAMF7⁺ CD4⁺ T cells in IgG4-RD.

Results

The patients with IgG4-RD enrolled in this study were aged 66 ± 12 years and their titers of serum IgG4 were 372 ± 336 mg/dl. Th1 cells, activated circulating Tfh1 (cTfh1), and activated cTfh2 cells increased in IgG4-RD. SLAMF7 was mainly expressed on Th1 and cTfh1, but not cTfh2, cells in the patients. SLAMF7^+</

SUBMITTER: Higashioka K 

PROVIDER: S-EPMC7268355 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature