Histologic subtyping affecting outcome of triple negative breast cancer: a large Sardinian population-based analysis.

ABSTRACT:

Background

Triple Negative breast cancer (TNBC) includes a heterogeneous group of tumors with different clinico-pathological features, molecular alterations and treatment responsivity. Our aim was to evaluate the clinico-pathological heterogeneity and prognostic significance of TNBC histologic variants, comparing "special types" to high-grade invasive breast carcinomas of no special type (IBC-NST).

Methods

This study was performed on data obtained from TNBC Database, including pathological features and clinical records of 1009 TNBCs patients diagnosed between 1994 and 2015 in the four most important Oncology Units located in different hospitals in Sardinia, Italy. Kaplan-Meier analysis, log-rank test and multivariate Cox proportional-hazards regression were applied for overa

SUBMITTER: Sanges F 

PROVIDER: S-EPMC7268380 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature