Influence of gender in monocrotaline and chronic hypoxia induced pulmonary hypertension in obese rats and mice.

ABSTRACT:

Background

Obesity and pulmonary hypertension (PH) share common characteristics, such as augmented inflammation and oxidative stress. However, the exact role of obesity in the pathology of PH is largely uninvestigated. Therefore, we have hypothesized that in the context of obesity the gender difference may have influence on development of PH in animal models of this disease.

Methods

Animal experiments were conducted in monocrotaline (MCT) and chronic hypoxia (HOX) models of PH. Lean and obese Zucker rats or B6 mice of both genders were used for MCT or HOX models, respectively. Echocardiography, hemodynamic measurements, histology and immuno-histochemistry were performed to analyze various parameters, such as right ventricular function and hypertrophy, hemodynamics, pulmonary

SUBMITTER: Neupane B 

PROVIDER: S-EPMC7268383 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature