Testing for causality between systematically identified risk factors and glioma: a Mendelian randomization study.

ABSTRACT:

Background

Whilst epidemiological studies have provided evidence of associations between certain risk factors and glioma onset, inferring causality has proven challenging. Using Mendelian randomization (MR), we assessed whether associations of 36 reported glioma risk factors showed evidence of a causal relationship.

Methods

We performed a systematic search of MEDLINE from inception to October 2018 to identify candidate risk factors and conducted a meta-analysis of two glioma genome-wide association studies (5739 cases and 5501 controls) to form our exposure and outcome datasets. MR analyses were performed using genetic variants to proxy for candidate risk factors. We investigated whether risk factors differed by subtype diagnosis (either glioblastoma (n = 3112) or non-gliobl

SUBMITTER: Howell AE 

PROVIDER: S-EPMC7268455 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature