Aflatoxins as a risk factor for liver cirrhosis: a systematic review and meta-analysis.

ABSTRACT:

Background

Liver cirrhosis is characterized by fibrosis and nodule formation in the liver, due to a chronic injury, and subsequent alteration of the normal architecture of the liver. Even though there is a huge effort to elucidate the possible etiologic factors of liver cirrhosis, a significant number of cases are cryptogenic, especially in Sub Saharan Africa, where there is a high burden of aflatoxin exposure. Aflatoxins are known to cause hepatocellular carcinoma, which share similar etiologic factors with liver cirrhosis. This study aimed to assess the association between aflatoxin exposure and the risk of liver cirrhosis.

Methods

Relevant studies were identified through systematic searches conducted in Ovid MEDLINE, PubMed and Google Scholar. Also, by searching the refer

SUBMITTER: Mekuria AN 

PROVIDER: S-EPMC7268458 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature