DNA methylation loci in placenta associated with birthweight and expression of genes relevant for early development and adult diseases.

ABSTRACT:

Background

Birthweight marks an important milestone of health across the lifespan, including cardiometabolic disease risk in later life. The placenta, a transient organ at the maternal-fetal interface, regulates fetal growth. Identifying genetic loci where DNA methylation in placenta is associated with birthweight can unravel genomic pathways that are dysregulated in aberrant fetal growth and cardiometabolic diseases in later life.

Results

We performed placental epigenome-wide association study (EWAS) of birthweight in an ethnic diverse cohort of pregnant women (n = 301). Methylation at 15 cytosine-(phosphate)-guanine sites (CpGs) was associated with birthweight (false discovery rate (FDR) < 0.05). Methylation at four (26.7%) CpG sites was associated with placental transcrip

SUBMITTER: Tekola-Ayele F 

PROVIDER: S-EPMC7268466 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature