Distinctions between sex and time in patterns of DNA methylation across puberty.

ABSTRACT:

Background

There are significant sex differences in human physiology and disease; the genomic sources of these differences, however, are not well understood. During puberty, a drastic neuroendocrine shift signals physical changes resulting in robust sex differences in human physiology. Here, we explore how shifting patterns of DNA methylation may inform these pathways of biological plasticity during the pubertal transition. In this study we analyzed DNA methylation (DNAm) in saliva at two time points across the pubertal transition within the same individuals. Our purpose was to compare two domains of DNAm patterns that may inform processes of sexual differentiation 1) sex related sites, which demonstrated differences between males from females and 2) time related sites in which DNA

SUBMITTER: Moore SR 

PROVIDER: S-EPMC7268482 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature