Unraveling the molecular interactions involved in phase separation of glucocorticoid receptor.

ABSTRACT:

Background

Functional compartmentalization has emerged as an important factor modulating the kinetics and specificity of biochemical reactions in the nucleus, including those involved in transcriptional regulation. The glucocorticoid receptor (GR) is a ligand-activated transcription factor that translocates to the nucleus upon hormone stimulation and distributes between the nucleoplasm and membraneless compartments named nuclear foci. While a liquid-liquid phase separation process has been recently proposed to drive the formation of many nuclear compartments, the mechanisms governing the heterogeneous organization of GR in the nucleus and the functional relevance of foci formation remain elusive.

Results

We dissected some of the molecular interactions involved in the formati

SUBMITTER: Stortz M 

PROVIDER: S-EPMC7268505 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature