Efficacy of mesenchymal stem cell therapy for sepsis: a meta-analysis of preclinical studies.

ABSTRACT:

Background

Multiple studies have reported that mesenchymal stem cell (MSC) therapy has beneficial effects in experimental models of sepsis. However, this finding remains inconclusive. This study was performed to systematically determine the connection between MSC therapy and mortality in sepsis animal models by pooling and analyzing data from newly published studies.

Methods

A detailed search of related studies from 2009 to 2019 was conducted in four databases, including MEDLINE, EMBASE, Cochrane Library, and Web of Science. After browsing and filtering out articles that met the inclusion criteria for statistical analysis, the inverse variance method of the fixed effects model was used to calculate the pooled odds ratios (ORs) and their 95% confidence intervals (CIs).

Res

SUBMITTER: Sun XY 

PROVIDER: S-EPMC7268531 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature