Altered gut microbiota in infants is associated with respiratory syncytial virus disease severity.

ABSTRACT:

Background

Respiratory syncytial virus (RSV) is the number one cause of lower respiratory tract infections in infants. There are still no vaccines or specific antiviral therapies against RSV, mainly due to the inadequate understanding of RSV pathogenesis. Recent data suggest a role for gut microbiota community structure in determining RSV disease severity. Our objective was to determine the gut microbial profile associated with severe RSV patients, which could be used to help identify at-risk patients and develop therapeutically protective microbial assemblages that may stimulate immuno-protection.

Results

We enrolled 95 infants from Le Bonheur during the 2014 to 2016 RSV season. Of these, 37 were well-babies and 58 were hospitalized with RSV. Of the RSV infected babies, 53

SUBMITTER: Harding JN 

PROVIDER: S-EPMC7268675 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature