Precursor peptide-targeted mining of more than one hundred thousand genomes expands the lanthipeptide natural product family.

ABSTRACT:

Background

Lanthipeptides belong to the ribosomally synthesized and post-translationally modified peptide group of natural products and have a variety of biological activities ranging from antibiotics to antinociceptives. These peptides are cyclized through thioether crosslinks and can bear other secondary post-translational modifications. While lanthipeptide biosynthetic gene clusters can be identified by the presence of genes encoding characteristic enzymes involved in the post-translational modification process, locating the precursor peptides encoded within these clusters is challenging due to their short length and high sequence variability, which limits the high-throughput exploration of lanthipeptide biosynthesis. To address this challenge, we enhanced the predictive capabil

SUBMITTER: Walker MC 

PROVIDER: S-EPMC7268733 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature