Structured decision-making drives guidelines panels' recommendations "for" but not "against" health interventions.

ABSTRACT:

Background and objectives

The determinants of guideline panels' recommendations remain uncertain. The objective of this study was to investigate factors considered by members of 8 panels convened by the American Society of Hematology (ASH) to develop guidelines using Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system.

Study design and setting

Web-based survey of the participants in the ASH guidelines panels.

Analysis

two-level hierarchical, random-effect, multivariable regression analysis to explore the relation between GRADE and non-GRADE factors and strength of recommendations (SOR).

Results

In the primary analysis, certainty in evidence [OR = 1.83; (95CI% 1.45-2.31)], balance of benefits and harms [OR = 1.49 (95CI% 1.30-1.69)]

SUBMITTER: Djulbegovic B 

PROVIDER: S-EPMC7268742 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature