DAMEfinder: a method to detect differential allele-specific methylation.

ABSTRACT:

Background

DNA methylation is a highly studied epigenetic signature that is associated with regulation of gene expression, whereby genes with high levels of promoter methylation are generally repressed. Genomic imprinting occurs when one of the parental alleles is methylated, i.e., when there is inherited allele-specific methylation (ASM). A special case of imprinting occurs during X chromosome inactivation in females, where one of the two X chromosomes is silenced, to achieve dosage compensation between the sexes. Another more widespread form of ASM is sequence dependent (SD-ASM), where ASM is linked to a nearby heterozygous single nucleotide polymorphism (SNP).

Results

We developed a method to screen for genomic regions that exhibit loss or gain of ASM in samples from two

SUBMITTER: Orjuela S 

PROVIDER: S-EPMC7268773 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature