Total DNA methylation as a biomarker of DNA damage and tumor malignancy in intracranial meningiomas.

ABSTRACT:

Background

Meningiomas are the most common primary intracranial tumors in adults. They are initially detected with neuroimaging techniques, but definite histological diagnosis requires tumor surgery to collect tumor tissue. Gross total resection is an optimal and final treatment for the majority of patients, followed by radiotherapy in malignant or refractory cases. However, there are a lot of uncertainties about i.a. the need for intervention in incidental cases, estimation of growth kinetics, risk of malignant transformation, or response to radiotherapy. Therefore a new diagnostic approach is needed. It has already been shown that epigenetics plays a crucial role in cancer biology, development, and progression. DNA methylation, the presence of 5-methylcytosine in DNA, is one of t

SUBMITTER: Barciszewska AM 

PROVIDER: S-EPMC7268775 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature