Decidual CD8⁺T cells exhibit both residency and tolerance signatures modulated by decidual stromal cells.

ABSTRACT:

Background

During early pregnancy, tolerance of the semi-allogeneic fetus necessitates comprehensive modifications of the maternal immune system. How decidual CD8⁺T (CD8⁺dT) cells balance maternal tolerance of the fetus with defense from invading pathogens remains undefined.

Methods

We investigated the distribution patterns of CD8⁺T cells and their heterogeneity in paired peripheral blood and decidual tissue in the first trimester of pregnancy using flow cytometry and mRNA-Seq. Gene Set Enrichment Analysis was utilized to determine the transcriptional features of CD8⁺dT cells. Moreover, we examined activation of T cells when they were cocultured with trophoblasts, in addition to the effect of the fetal-maternal environment on perip

SUBMITTER: Liu L 

PROVIDER: S-EPMC7268777 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature