IFITM3 affects the level of antibody response after influenza vaccination.

ABSTRACT: Interferon-induced transmembrane protein 3 (IFITM3) as an antiviral factor can inhibit replication of several viruses including influenza virus. A single-nucleotide polymorphism rs12252-C of IFITM3 results in a truncated IFITM3 protein lacking its first 21 amino acids, which is much higher in the Han Chinese population and associated with severe illness in adults infected with pandemic influenza H1N1/09 virus. To investigate if IFITM3 or IFITM3 rs12252-C could affect the antibody response after influenza vaccination, we detected the haemagglutination inhibition (HI) of 171 healthy young adult volunteers (IFITM3 rs12252-C/C, C/T, T/T carriers) and in an IFITM3-deletion mouse model (Ifitm3^-/-) after trivalent inactivated vaccine (TIV) immunization. Sero

SUBMITTER: Lei N 

PROVIDER: S-EPMC7269036 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature