Presence and persistence of hepatitis E virus RNA and proteins in human bone marrow.
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ABSTRACT:
SUBMITTER: Wang L
PROVIDER: S-EPMC7269076 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Publications
Presence and persistence of hepatitis E virus RNA and proteins in human bone marrow.
Wang Lin L Yan Li L Jiang Jieling J Zhang Yuyi Y He Qiyu Q Zhuang Hui H Wang Ling L
Emerging microbes & infections 20201201 1
Hepatitis E virus (HEV) infection is primarily manifesting as acute hepatitis, but extra-hepatic replication and injury are frequently reported. During the study period, we discovered two acute myeloid leukaemia (AML) patients infected with HEV genotype 3 and 4, respectively, and HEV RNA and/or viral proteins were persistently detected in the bone marrow of both patients. The finding suggests that HEV can replicate in human bone marrow as it may serve as a new target site and reservoir of HEV pe ...[more]
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