Perturbations of the Gut Microbiome and Metabolome in Children with Calcium Oxalate Kidney Stone Disease.

ABSTRACT:

Background

The relationship between the composition and function of gut microbial communities and early-onset calcium oxalate kidney stone disease is unknown.

Methods

We conducted a case-control study of 88 individuals aged 4-18 years, which included 44 individuals with kidney stones containing ≥50% calcium oxalate and 44 controls matched for age, sex, and race. Shotgun metagenomic sequencing and untargeted metabolomics were performed on stool samples.

Results

Participants who were kidney stone formers had a significantly less diverse gut microbiome compared with controls. Among bacterial taxa with a prevalence >0.1%, 31 taxa were less abundant among individuals with nephrolithiasis. These included seven taxa that produce butyrate and three taxa that degrade oxalate.

SUBMITTER: Denburg MR 

PROVIDER: S-EPMC7269359 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature