Metabolism of Benzalkonium Chlorides by Human Hepatic Cytochromes P450.

ABSTRACT: Benzalkonium chlorides (BACs) are widely used as disinfectants in cleaning products, medical products, and the food processing industry. Despite a wide range of reported toxicities, limited studies have been conducted on the metabolism of these compounds in animal models and none in human-derived cells or tissues. In this work, we report on the metabolism of BACs in human liver microsomes (HLM) and by recombinant human hepatic cytochrome P450 (CYP) enzymes. BAC metabolism in HLM was NADPH-dependent and displayed apparent half-lives that increased with BAC alkyl chain length (C₁₀ < C₁₂ < C₁₄ < C₁₆), suggesting enhanced metabolic stability of the more lipophilic, longer chain BACs. Metabolites of d₇-benzyl labeled BAC substrates r

SUBMITTER: Seguin RP 

PROVIDER: S-EPMC7269367 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature