TFEB is a master regulator of tumor-associated macrophages in breast cancer.

ABSTRACT:

Background

Tumor-associated macrophages (TAMs) play key roles in the development of many malignant solid tumors including breast cancer. They are educated in the tumor microenvironment (TME) to promote tumor growth, metastasis, and therapy resistance. However, the phenotype of TAMs is elusive and how to regulate them for therapeutic purpose remains unclear; therefore, TAM-targeting therapies have not yet achieved clinical success. The purposes of this study were to examine the role of transcription factor EB (TFEB) in regulating TAM gene expression and function and to determine if TFEB activation can halt breast tumor development.

Methods

Microarrays were used to analyze the gene expression profile of macrophages (MΦs) in the context of breast cancer and to examine the impac

SUBMITTER: Li Y 

PROVIDER: S-EPMC7269543 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature