Functional specification of CCK+ interneurons by alternative isoforms of Kv4.3 auxiliary subunits.

ABSTRACT: CCK-expressing interneurons (CCK+INs) are crucial for controlling hippocampal activity. We found two firing phenotypes of CCK+INs in rat hippocampal CA3 area; either possessing a previously undetected membrane potential-dependent firing or regular firing phenotype, due to different low-voltage-activated potassium currents. These different excitability properties destine the two types for distinct functions, because the former is essentially silenced during realistic 8-15 Hz oscillations. By contrast, the general intrinsic excitability, morphology and gene-profiles of the two types were surprisingly similar. Even the expression of Kv4.3 channels were comparable, despite evidences showing that Kv4.3-mediated currents underlie the distinct firing properties. Instead, the firing phenotypes wer

SUBMITTER: Olah VJ 

PROVIDER: S-EPMC7269670 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature