Intake of Furocoumarins and Risk of Skin Cancer in 2 Prospective US Cohort Studies.

ABSTRACT:

Background

In prior studies, higher citrus consumption was associated with higher risk of cutaneous malignant melanoma, squamous cell carcinoma (SCC), and basal cell carcinoma (BCC). Furocoumarins, compounds with phototoxicity and photocarcinogenicity in citrus, may be responsible for the association.

Objectives

The objective of the study was to investigate the association between furocoumarin intake and skin cancer risk.

Methods

A total of 47,453 men from the Health Professionals Follow-Up Study (HPFS) and 75,291 women from the Nurses' Health Study (NHS) with diet data collected every 2-4 y in the 2 prospective cohort studies were included. A furocoumarin food composition database for 7 common furocoumarins [bergaptol, psoralen, 8-methoxypsoralen, bergapten, 6',7'-di

SUBMITTER: Sun W 

PROVIDER: S-EPMC7269730 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature